Celiac Disease Diagnosis is difficult, because it is a genetic disorder. Currently, the only gold standard for confirming celiac disease diagnosis is to biopsy part of the small intestine with a biopsy tool called a bioscope to look for symptoms of villous atrophy, which can be a sign of celiac disease. However, in a study published in June 2021 in the Archives of Internal Medicine, editors noted that many experts were now recommending an entirely different method of celiac disease diagnosis: genetics, not biopsies, are the best tools for this job. More than half of the people with celiac disease do not have villi atrophy, and these patients may not even have symptoms of damage to their small intestines, according to research. Hence, it’s not worth the effort or expense to undergo a biopsy to find out if one has celiac disease, researchers believe.
One involves collecting a sample of the patient’s blood, and testing it for gluten in feces and seroconversion analyses. The second involves the detection of anti-gliadin and immunoglobulin antibodies in blood samples. These blood tests can help doctors rule out other digestive disorders such as leaky gut syndrome and coeliac sprue and can also provide them with celiac disease diagnosis.
After a biopsy, doctors will likely perform a series of laboratory tests in order to confirm celiac disease diagnosis. These include a serological blood test, where antibody-specific antibodies will be detected against a protein called gluten. The disease causes an allergic reaction in the small intestine, causing damage to the inner lining and preventing nutrients from properly being absorbed into the bloodstream. If the body’s immune system recognizes this protein as foreign particles, it attacks these foreign substances causing inflammation in the intestine. The release of these inflammatory antibodies is what leads to symptoms such as diarrhea, weight loss, and anemia.
A conclusive diagnosis may only be possible through a biopsy. However, even if a patient is found to have celiac disease, the doctor may still recommend that the patient follow a gluten-free or gluten-free diet. This way, there will still be vitamins and minerals present in the food that the patient needs. Since some people are sensitive to gluten, especially those with malabsorptive disorders, this dietary modification may still be necessary.
Gluten-Sensitive Enterococcus Faecalis Microbe
An important part of diagnosing celiac disease involves the use of a gluten-sensitive Enterococcus faecalis microbe. This organism is found naturally in the gut of humans. It can grow unfailingly if the person suffers from non-celiac gluten sensitivity. When it is exposed to gluten, it will grow and multiply, causing inflammation. If a biopsy shows that a person has celiac, doctors will then confirm this diagnosis by performing a biopsy of the duodenum.
These tests usually include a serological test called a celiac albumin level. This test can reveal whether a person has celiac disease if gluten is detected in his blood tests. The other common blood test used for this purpose is an antibody to gliadin, which is responsible for the lining of the small intestines.
Mimic Celiac Disease Symptoms
In order to rule out other diseases that can mimic celiac disease symptoms, doctors may also conduct blood tests that measure the immune system response to gluten. These tests, however, are not perfect and may result in a false-positive result, so it is important that the patient should also undergo laboratory tests in order to confirm his or her condition.
A conclusive diagnosis can only be achieved through performing blood tests that are both sensitive and specific at the same time. This is why it is always advisable to get your blood tested first, before embarking on a gluten-free diet. Your doctor may also send you to have a biopsy done in order to obtain more accurate results regarding your condition.
If you do not have a serological test for celiac disease, then you can always rely on genetic testing. If you have a family history of this condition, there is a higher chance that you may develop it as well. If one of your parents had it, you have a big possibility of being able to develop it as well. However, since no direct genetic relationship between any of us and this condition exists, genetic testing cannot be used as an effective gluten sensitivity test. However, genetic testing will be able to provide you with the necessary information you need in order to find out if your diet contains gluten or not.