What Do You Not Know About Celiac Disease Pathophysiology

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Celiac disease is a disease in which the protein gluten in cereal products damages the lining of the small intestinal mucosa in people with a hereditary predisposition to the disease. Some patients also have skin symptoms (see Skin celiac disease).  In population surveys, celiac disease has been diagnosed in about 2 per cent of people. Cutaneous celiac disease occurs in approximately 10% of adult celiac patients.

What Do Further Study States?

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Two-thirds of those with intestinal celiac disease are women, and skin celiac disease is common in men. Celiac disease often occurs in families. If someone in the family has celiac disease, other family members have a one in ten chance of celiac disease. Celiac disease can manifest as a variety of symptoms at any age. It is most commonly seen in adulthood but can occur as early as infancy or in old age.


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The symptoms may be similar to those of irritable bowel syndrome. Weight loss is a classic symptom of celiac disease, but today most patients are normal or overweight. The condition is often associated with a disorder of nutrient absorption, resulting in a deficiency of some nutrients. The most common are iron deficiency anemia, vitamin D deficiency, and secondary lactose intolerance caused by intestinal damage.

Causes Of Celiac Disease

Celiac disease is caused by the protein gluten found in wheat, rye and barley. In hereditary susceptible individuals, it damages, apparently through an immunological reaction, the cells of the mucosa that envelop the inner surface of the small intestine. As a result, the lining layer of the mucosa atrophy interferes with the absorption of nutrients from the intestine through the cells into the bloodstream? Celiac disease is an autoimmune disease with a tendency to form antibodies against your tissues. Therefore, other autoimmune diseases, such as type 1 diabetes and thyroid diseases, are more common in celiac disease than in the general population.

Detection Of celiac disease

Celiac disease studies are appropriate if appropriate gastric symptoms, malabsorption or rash suitable for cutaneous celiac disease are present. The primary initial research is the so-called determination of transglutaminase antibodies by a blood test. The study is supplemented by determining the so-called endomysial antibodies, which is a reliable sign of celiac disease. Typically, the diagnosis can be made by antibody testing alone without small bowel endoscopy.

What If The Diagnosis Can’t Be Made?

If the diagnosis cannot be made based on sufficiently high antibody levels, the diagnosis of celiac disease is confirmed by microscopic examination of the intestinal sample. The sample is taken under gastric investigation, in which case the speculum is moved to the side of the small intestine. Skin celiac disease is confirmed based on a sample taken from healthy skin. In cutaneous celiac disease, blood celiac antibodies do not rise in about one-third of cutaneous celiac disease.

Summing Up 

The treatment is a permanently gluten-free diet, which is the only effective treatment for celiac disease. Diets that contain entirely wheat, rye, and barley are wholly avoided in the diet and replaced with gluten-free products. The treatment is lifelong and should aim to avoid these grains as closely as possible. Gluten-free oats are suitable for people with celiac disease when used moderately. Diet therapy is initiated under the guidance of a nutritionist. For more information on diet therapy.

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